Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13873069 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNADPP4KMT2ANPC1 | |
| SCHEMBL24814982 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNACSNK1ERORCKCNQ3 | |
| SCHEMBL18754890 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNADPP4KMT2APOLB | |
| SCHEMBL19011774 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNADPP4KMT2ARAB9A | |
| SCHEMBL19011564 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNADPP4KMT2APOLB | |
| SCHEMBL22996454 | 0.81 | POLB (0.48) | SMN1; SMN2LMNAVNN1KMT2ANPC1 | |
| SCHEMBL22182484 | 0.81 | POLB (0.48) | SMN1; SMN2LMNAVNN1KMT2ANPC1 | |
| SCHEMBL22996452 | 0.81 | POLB (0.48) | SMN1; SMN2LMNAVNN1KMT2ANPC1 | |
| SCHEMBL24158945 | 0.79 | VNN1 (0.38) | SMN1; SMN2LMNAVNN1DPP4KMT2A | |
| SCHEMBL20837002 | 0.79 | VNN1 (0.38) | SMN1; SMN2LMNAVNN1DPP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167110-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | SCHRÖDINGER, INC. | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167110-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | JAK2, JAK3, STAT5B | SMN1; SMN2 4718/4885LMNA 4393/4885VNN1 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.