Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 17/20 | 0.44 |
| ▸ | CDK2 | P24941 | 17/20 | 0.44 |
| ▸ | CCNK | O75909 | 17/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 17/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 16/20 | 0.44 |
| ▸ | CDK9 | P50750 | 16/20 | 0.44 |
| ▸ | CDK7 | P50613 | 10/20 | 0.41 |
| ▸ | CCNH | P51946 | 10/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25595093 | 0.90 | CCNK (0.43) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581352 | 0.90 | CCNE1 (0.41) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581305 | 0.89 | CDK7 (0.45) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25583028 | 0.88 | CCNE1 (0.38) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581348 | 0.88 | CCNK (0.39) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25583323 | 0.86 | CDK7 (0.39) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581350 | 0.86 | CCNK (0.39) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581358 | 0.86 | CCNE1 (0.38) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581351 | 0.85 | LCK (0.39) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL25581306 | 0.84 | PTK2 (0.46) | CCNE1CDK2CCNKCDK12CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186895-A1 | COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF | TYK Medicines Inc. (CN) | 2023-05-31 | — | — | EP | disclosed |