Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | BLM | P54132 | 4/20 | 0.60 |
| ▸ | RECQL | P46063 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | APEX1 | P27695 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13644181 | 0.85 | KDM4E (0.70) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL25846202 | 0.82 | KDM4E (0.76) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL13431276 | 0.82 | KDM4E (0.76) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL19368947 | 0.80 | HSD17B10 (0.61) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL15920346 | 0.78 | HSD17B10 (0.78) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL2600039 | 0.78 | ALOX15 (0.59) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| Methyldopa (Racemic) SCHEMBL28969518 | 0.76 | KDM4E (0.94) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL23754771 | 0.75 | KDM4E (0.76) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| Methyldopa SCHEMBL34003 | 0.75 | KDM4E (1.00) | KDM4EHSD17B10ALOX15HPGDMAPT | |
| SCHEMBL23754770 | 0.75 | KDM4E (0.76) | KDM4EHSD17B10ALOX15HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666539-B2 | Synthetic lipid-like materials for brain delivery | TRUSTEES OF TUFTS COLLEGE (US) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666539-B2 | Synthetic lipid-like materials for brain delivery | NPC1L1, FABP7, LIPA | KDM4E 3759/4885HSD17B10 510/4885ALOX15 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.