Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.65 |
| ▸ | CCNK | O75909 | 9/20 | 0.65 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.65 |
| ▸ | CDK9 | P50750 | 8/20 | 0.65 |
| ▸ | CDK7 | P50613 | 10/20 | 0.58 |
| ▸ | CCNH | P51946 | 10/20 | 0.58 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.52 |
| ▸ | JUN | P05412 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30204470 | 1.00 | CDK2 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL25593182 | 0.90 | CDK2 (0.63) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL27128063 | 0.85 | CDK7 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL26967460 | 0.85 | CDK7 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL25600682 | 0.82 | CDK7 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL30204073 | 0.82 | CDK7 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL29492498 | 0.82 | CCNK (0.57) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL25600689 | 0.82 | CDK7 (0.65) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL30204515 | 0.81 | CDK2 (0.49) | CDK2CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL25598586 | 0.81 | CDK2 (0.49) | CDK2CCNKCDK12CCNT1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |