Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559123 | 0.89 | KDM4E (0.60) | KDM4EGSTO1ABL1RAB9ANPC1 | |
| SCHEMBL2556748 | 0.88 | NPC1 (0.58) | KDM4EABL1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2555806 | 0.87 | KDM4E (0.63) | KDM4EABL1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2558993 | 0.86 | KDM4E (0.56) | KDM4EABL1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2557090 | 0.85 | KDM4E (0.63) | KDM4EGSTO1ABL1RAB9ANPC1 | |
| SCHEMBL2556997 | 0.85 | KDM4E (0.63) | KDM4EGSTO1ABL1RAB9ANPC1 | |
| SCHEMBL2558948 | 0.85 | KDM4E (0.63) | KDM4EABL1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2554299 | 0.85 | ABL1 (0.67) | KDM4EGSTO1ABL1RAB9ANPC1 | |
| SCHEMBL2554108 | 0.85 | KDM4E (0.63) | KDM4EABL1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2560460 | 0.83 | KDM4E (0.61) | KDM4EABL1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |