Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | CFTR | P13569 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560048 | 0.88 | KDM4E (0.60) | NPC1RAB9AABL1SIRT5CSNK2A2 | |
| SCHEMBL2557829 | 0.86 | RAB9A (0.61) | NPC1RAB9ACFTRABL1SIRT5 | |
| SCHEMBL2557289 | 0.84 | RAB9A (0.61) | NPC1RAB9AABL1MAPTKDM4E | |
| SCHEMBL2559105 | 0.84 | RAB9A (0.61) | NPC1RAB9AABL1CSNK2A2CSNK2B | |
| SCHEMBL2558907 | 0.84 | ABL1 (0.65) | NPC1RAB9ACFTRABL1TRPA1 | |
| SCHEMBL2562338 | 0.83 | RAB9A (0.63) | NPC1RAB9AABL1MAPTKDM4E | |
| SCHEMBL2557090 | 0.82 | KDM4E (0.63) | NPC1RAB9AABL1MAPTKDM4E | |
| SCHEMBL2561621 | 0.82 | KDM4E (0.67) | NPC1RAB9AABL1CSNK2A2CSNK2B | |
| SCHEMBL2559658 | 0.81 | RAB9A (0.61) | NPC1RAB9AABL1MAPTKDM4E | |
| SCHEMBL2558952 | 0.81 | NPC1 (0.88) | NPC1RAB9AABL1SIRT5CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |