Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 20/20 | 0.74 |
| ▸ | MAOA | P21397 | 14/20 | 0.74 |
| ▸ | RCOR1 | Q9UKL0 | 9/20 | 0.74 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.74 |
| ▸ | MAOB | P27338 | 6/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816667 | 0.89 | KDM1A (0.73) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL14672849 | 0.89 | KDM1A (0.73) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL30816623 | 0.87 | KDM1A (0.80) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL2562143 | 0.87 | KDM1A (0.80) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL18952158 | 0.87 | KDM1A (0.71) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL18353842 | 0.85 | KDM1A (1.00) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL15944927 | 0.85 | KDM1A (1.00) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL15944932 | 0.85 | KDM1A (1.00) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL30816682 | 0.85 | KDM1A (0.74) | KDM1AMAOARCOR1KDM1BMAOB | |
| SCHEMBL2561894 | 0.85 | KDM1A (1.00) | KDM1AMAOARCOR1KDM1BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560949-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 | Università degli Studi di Roma "La Sapienza" (IT) | 2013-02-27 | — | — | EP | claimed |
| WO-2011131576-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 | UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) | 2011-10-27 | — | — | WO | claimed |
| WO-2017097865-A9 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017097865-A1 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-06-15 | — | — | WO | disclosed |