Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 5/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.51 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25601373 | 0.91 | KCNT1 (0.62) | KCNT1TDP1TP53SMN1; SMN2KCNQ1 | |
| SCHEMBL25601136 | 0.91 | KCNT1 (0.64) | KCNT1TDP1TP53SMN1; SMN2KCNQ1 | |
| SCHEMBL25601114 | 0.89 | KCNT1 (0.58) | KCNT1TDP1TP53SMN1; SMN2KCNQ1 | |
| SCHEMBL25601094 | 0.89 | KCNT1 (0.60) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL25601146 | 0.87 | PSEN1 (0.55) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL25601119 | 0.87 | TDP1 (0.57) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL25601131 | 0.87 | PSEN1 (0.55) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL25601287 | 0.85 | KCNT1 (0.54) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL25245935 | 0.84 | KCNT1 (0.71) | KCNT1TDP1KCNQ1KCNH2CACNA1C | |
| SCHEMBL25245937 | 0.84 | KCNT1 (0.71) | KCNT1TDP1KCNQ1KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | KCNT1 1/4885TDP1 1280/4885TP53 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.