Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 12/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.53 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25601373 | 0.93 | KCNT1 (0.62) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601100 | 0.91 | KCNT1 (0.62) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601397 | 0.89 | KCNT1 (0.72) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25217840 | 0.88 | KCNT1 (0.63) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601114 | 0.87 | KCNT1 (0.58) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601094 | 0.86 | KCNT1 (0.60) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601171 | 0.86 | KCNT1 (0.62) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601155 | 0.85 | KCNT1 (0.59) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601088 | 0.85 | KCNT1 (0.59) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 | |
| SCHEMBL25601445 | 0.84 | KCNT1 (0.58) | KCNT1TP53SMN1; SMN2KCNQ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | KCNT1 1/4885TP53 4492/4885SMN1; SMN2 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.