Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.70 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | TLR2 | O60603 | 3/20 | 0.50 |
| ▸ | NMT2 | O60551 | 1/20 | 0.47 |
| ▸ | NMT1 | P30419 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23685586 | 0.87 | SIRT6 (0.53) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL14004705 | 0.86 | SIRT6 (0.51) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL18806403 | 0.85 | SIRT6 (0.52) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL18916658 | 0.85 | SIRT6 (0.70) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL29444177 | 0.84 | SIRT6 (0.68) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL2789981 | 0.82 | SIRT6 (0.61) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL13331678 | 0.82 | SIRT6 (0.61) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL13997595 | 0.81 | SIRT6 (0.46) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL20964866 | 0.80 | SIRT6 (0.63) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL29397495 | 0.80 | SIRT6 (0.63) | SIRT6SIRT1CA1CA2TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133151-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PHENOL-MODIFIED OPIOID PRODRUGS AND INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133150-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133149-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-10-27 | — | — | WO | disclosed |