Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | IAPP | P10997 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243877 | 0.85 | ALDH1A1 (0.48) | ALDH1A1LMNAIAPPCYP4F2CYP4A11 | |
| SCHEMBL9394677 | 0.82 | CYP4F2 (0.51) | ALDH1A1PAOXLMNAIAPPCYP4F2 | |
| SCHEMBL6601966 | 0.81 | TAAR1 (0.48) | TAAR1ALDH1A1LMNAIAPP | |
| SCHEMBL3650689 | 0.81 | ALDH1A1 (0.46) | ALDH1A1PAOXLMNAIAPPCYP4F2 | |
| SCHEMBL29191321 | 0.79 | IAPP (0.58) | TAAR1ALDH1A1LMNAIAPP | |
| SCHEMBL29712399 | 0.78 | TAAR1 (0.47) | TAAR1ALDH1A1HTR2ALMNAIAPP | |
| SCHEMBL5182214 | 0.78 | TAAR1 (0.47) | TAAR1ALDH1A1LMNAIAPP | |
| SCHEMBL809020 | 0.78 | TAAR1 (0.47) | TAAR1ALDH1A1HTR2ALMNAIAPP | |
| SCHEMBL10882347 | 0.78 | ALDH1A1 (0.55) | ALDH1A1LMNAIAPP | |
| SCHEMBL28332846 | 0.76 | FOLH1 (0.58) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724188-B1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2023-06-07 | — | — | EP | disclosed |