Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.67 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577969 | 0.88 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL7454134 | 0.86 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1MEN1TP53 | |
| SCHEMBL10547998 | 0.81 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL9022295 | 0.81 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1FFAR1MEN1 | |
| SCHEMBL8907596 | 0.81 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL1695058 | 0.81 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL3271578 | 0.81 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL10544473 | 0.80 | CYSLTR1 (0.84) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL2561327 | 0.80 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 | |
| SCHEMBL10446852 | 0.80 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2GPBAR1FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |