Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.67 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.51 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.51 |
| ▸ | ULK1 | O75385 | 2/20 | 0.50 |
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861604 | 0.81 | MAPK10 (0.67) | ROCK2ROCK1CCR2ACKR3CTNNB1 | |
| SCHEMBL15022646 | 0.81 | ROCK2 (0.68) | ROCK2ROCK1CCR2 | |
| SCHEMBL15021912 | 0.81 | ROCK2 (0.68) | ROCK2ROCK1CCR2 | |
| SCHEMBL12282076 | 0.80 | TTK (0.66) | ROCK2ROCK1 | |
| SCHEMBL2571386 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1CCR2ULK1 | |
| Hydrochloric Acid SCHEMBL2568328 | 0.79 | TTK (0.65) | ROCK2ROCK1 | |
| SCHEMBL2866839 | 0.77 | ROCK2 (0.55) | ROCK2ROCK1CCR2ACKR3ULK1 | |
| SCHEMBL15021797 | 0.75 | ROCK2 (0.66) | ROCK2ROCK1CCR2 | |
| SCHEMBL17311705 | 0.74 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL1554194 | 0.74 | TDP1 (0.61) | ROCK2ROCK1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |