Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 20/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561018 | 1.00 | TTK (0.56) | TTKMAPK8AURKBINCENP | |
| SCHEMBL12282456 | 0.85 | TTK (0.77) | TTKAURKB | |
| SCHEMBL12282500 | 0.85 | TTK (0.77) | TTKAURKB | |
| SCHEMBL2591541 | 0.85 | TTK (0.77) | TTKAURKB | |
| SCHEMBL2570701 | 0.79 | ALDH1A1 (0.55) | — | |
| SCHEMBL2570699 | 0.79 | ALDH1A1 (0.55) | — | |
| SCHEMBL12282340 | 0.77 | TTK (0.66) | TTKAURKB | |
| SCHEMBL2565135 | 0.75 | TTK (0.78) | TTKMAPK8AURKB | |
| SCHEMBL12282371 | 0.72 | TTK (0.70) | TTKAURKB | |
| SCHEMBL12280943 | 0.72 | TTK (0.75) | TTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |