Known targets — ChEMBL curated mechanism
CSF1RFLT1FLT3FLT4KDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30036315 | 1.00 | — | — | |
| Malic Acid SCHEMBL14125844 | 1.00 | SMN1; SMN2 (1.00) | — | |
| Malic Acid SCHEMBL29410671 | 1.00 | SMN1; SMN2 (1.00) | — | |
| Malic Acid SCHEMBL31673489 | 1.00 | — | — | |
| Malic Acid SCHEMBL89131 | 1.00 | SMN1; SMN2 (1.00) | — | |
| Malic Acid SCHEMBL28355917 | 1.00 | SMN1; SMN2 (1.00) | — | |
| Malic Acid SCHEMBL31673494 | 1.00 | — | — | |
| Malic Acid SCHEMBL98496 | 1.00 | — | — | |
| Malic Acid SCHEMBL856 | 1.00 | — | — | |
| Malic Acid SCHEMBL30036864 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6341 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748371-A1 | RIFABUTIN COMPOSITIONS AND METHOD OF MAKING | BIOVERSYS AG (CH) | 2026-05-27 | — | — | EP | claimed |
| CN-117384932-B | Expression vector pHH40 and application thereof in construction of wine coccus engineering bacteria | QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES) (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122079867-A | Synthesis method of chiral delta-caprolactam compound | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026103747-A1 | SALT OF THIAZOLE DERIVATIVE INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2026-05-21 | — | — | WO | claimed |
| US-12630520-B2 | Left-handed bicyclic morpholine and salt thereof, preparation method therefor, pharmaceutical composition, and use | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2026-05-19 | — | — | US | claimed |
| CN-122056204-A | Cultivation medium for improving nutrition quality of black fungus and cultivation method thereof | 甘肃省农业科学院蔬菜研究所 | 2026-05-19 | — | — | CN | claimed |
| CN-122036503-A | Preparation method of aroyl malic acid | 华东理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122036704-A | Free base crystal form or acid salt of biaryl compound, preparation method and medical application thereof | 江苏豪森药业集团有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-3869192-B1 | METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE | HUMAN METABOLOMICS INST INC (CN) | 2026-05-13 | — | — | EP | claimed |
| CN-117384030-B | Production method of bio-based succinic acid | 中国石油天然气股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-1436802-A | Aliphatic polyester with hydrophilic functional lateral group and its prepn and use | SHANGHAI INST ORGANIC CHEM (CN) | 2003-08-20 | — | — | CN | claimed |
| CN-1117744-C | 1- (1, 2-disubstituted piperidinyl) -4-substituted piperazine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | CN | claimed |
| CN-1390194-A | Stable salts of novel derivatives of 3, 3-diphenylpropylamines | SANOL ARZNEI SCHWARZ GMBH (DE) | 2003-01-08 | — | — | CN | claimed |
| CN-1205699-A | 1- (1, 2-disubstituted piperidinyl) -4-substituted piperazine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-20 | — | — | CN | claimed |
| CN-1143635-A | Stereoselective synthesizing process for enantiomorph pure 3-amino-1,2-twice substituted pyrrolidine | UNIV XIAMEN (CN) | 1997-02-26 | — | — | CN | claimed |
| EP-0708763-A1 | PROCESS FOR MAKING HIV PROTEASE INHIBITORS | MERCK & CO. INC. (US) | 1996-05-01 | — | — | EP | claimed |
| WO-1995002583-A1 | PROCESS FOR MAKING HIV PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 1995-01-26 | — | — | WO | claimed |
| CN-1037512-A | Preparation method and application of dextro photoisomer of dihydropyridine-3, 5-dicarboxylate derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1989-11-29 | — | — | CN | claimed |
| CN-85103418-A | Preparation method of dihydropyridine-3, 5-dicarboxylic ester derivative | — | 1986-10-15 | — | — | CN | claimed |
| EP-0149885-A2 | Method of resolving a racemic mixture | Kabushiki Kaisha Vitamin Kenkyusyo (JP) | 1985-07-31 | — | — | EP | claimed |