Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.55 |
| ▸ | TET3 | O43151 | 2/20 | 0.55 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.55 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.52 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30036315 | 1.00 | — | — | |
| Malic Acid SCHEMBL14125844 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29410671 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673489 | 1.00 | — | — | |
| Malic Acid SCHEMBL256122 | 1.00 | — | — | |
| Malic Acid SCHEMBL28355917 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673494 | 1.00 | — | — | |
| Malic Acid SCHEMBL98496 | 1.00 | — | — | |
| Malic Acid SCHEMBL856 | 1.00 | — | — | |
| Malic Acid SCHEMBL30036864 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753635-B2 | Methods and systems and related compositions for mixtures separation with a solid matrix | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | claimed |
| WO-2022051419-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISRUPTION | HERBALIFE INTERNATIONAL OF AMERICA, INC. (US) | 2022-03-10 | — | — | WO | claimed |
| US-20220049242-A1 | METHODS AND SYSTEMS AND RELATED COMPOSITIONS FOR MIXTURES SEPARATION WITH A SOLID MATRIX | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-02-17 | — | — | US | claimed |
| CN-121545750-B | Individual dynamic metabolism abnormality early warning system based on functional data analysis | Hangzhou Institute of advanced studies National University of science and technology (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-122095072-A | Fruit-based or other type of alcoholic beverage production | — | 2026-05-26 | — | — | CN | disclosed |
| CN-121574789-A | Fermented beverage rich in alpha-ketoglutaric acid and organic acid and preparation method thereof | 现代发酵技术研究院(山西)有限公司 | 2026-02-27 | — | — | CN | disclosed |
| EP-4688705-A1 | COMPOSITION COMPRISING A PROTEIN HYDROLYSATE AND A MICROALGAE EXTRACT AND USE THEREOF AS AN AGRICULTURAL BIOSTIMULANT | FERTIVAL (FR) | 2026-02-11 | — | — | EP | disclosed |
| US-20260034177-A1 | HUMAN FUNCTIONAL CORNEAL ENDOTHELIAL CELL AND APPLICATION THEREOF | KYOTO PREFECTURAL PUBLIC UNIV CORP (JP) | 2026-02-05 | — | — | US | disclosed |
| CN-120025996-A | Synechococcus (Fr.) Kummer malate dehydrogenase | 安徽师范大学 | 2025-05-23 | — | — | CN | disclosed |
| CN-119999701-A | Low-phosphorus growth-promoting strain separated from arabidopsis root system microbial community and application thereof | 中国科学院遗传与发育生物学研究所 | 2025-05-16 | — | — | CN | disclosed |
| CN-113969289-B | Application of sinapic acid in plant stomata opening and closing regulation | 河南大学 | 2025-04-25 | — | — | CN | disclosed |
| EP-2177646-B1 | Stress-reduced Ni-P/Pd stacks for bondable wafer surfaces | ATOTECH DEUTSCHLAND GMBH (DE) | 2011-03-23 | — | — | EP | disclosed |
| EP-2231588-A1 | ORGANIC SALTS OF -ALANINE | Northern Innovations and Formulations Corp. (CA) | 2010-09-29 | — | — | EP | disclosed |
| US-7754943-B2 | Transgenic plants used as a bioreactor system | BSES LIMITED (AU) | 2010-07-13 | — | — | US | disclosed |
| WO-2009073947-A1 | ORGANIC SALTS OF β-ALANINE | IOVATE T. & P. INC. (CA) | 2009-06-18 | — | — | WO | disclosed |
| US-20060259998-A1 | Transgenic plants used as a bioreactor system | BUREAU OF SUGAR EXPERIMENT STATIONS (AU) | 2006-11-16 | — | — | US | disclosed |
| EP-1702056-A2 | NON-ANIMAL PRODUCT CONTAINING VETERINARY FORMULATIONS | Merial Limited (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005062782-A2 | NON-ANIMAL PRODUCT CONTAINING VETERINARY FORMULATIONS | MERIAL LIMITED (US) | 2005-07-14 | — | — | WO | disclosed |
| US-4629690-A | COMPETITIVE PROTEIN BINDING USING A SECOND ENZYME RELATED TO THE FIRST BY THE PRODUCT OF ONE BEING THE SUBSTRATE OF THE OTHER | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| US-4483942-A | CITRIC OR MALIC ACID AS STABILIZER | NIPPON OIL CO., LTD. (JP) | 1984-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260034177-A1 | HUMAN FUNCTIONAL CORNEAL ENDOTHELIAL CELL AND APPLICATION THEREOF | EPCAM, CD44, SLC17A5 | SMN1; SMN2 4697/4885SLC22A6 126/4885TET2 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.