SCHEMBL25614277

SCHEMBL25614277

C[Si](C)(C)C#Cc1cncc(N2CC3CC3C2)c1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 13/20 0.46
CHRNA4 P43681 13/20 0.46
CHRNB4 P30926 12/20 0.46
CHRNA3 P32297 12/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30811670 0.85 CHRNB4 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL15132388 0.83 CHRNB4 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL29176234 0.80 CHRNB2 (0.40) CHRNB2CHRNA4
SCHEMBL29107985 0.80 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL30811822 0.80 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL30811810 0.80 CHRNB2 (0.40) CHRNB2CHRNA4
SCHEMBL30811812 0.79 CHRNB2 (0.43) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL30811756 0.79 CHRNB2 (0.43) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL29176197 0.79 CHRNB2 (0.43) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL29108017 0.79 CHRNB2 (0.39) CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023104209-A1 METTL3 INHIBITOR COMPOUND 上海昂阔医药有限公司 2023-06-15 WO disclosed