SCHEMBL2561828

SCHEMBL2561828

O=Cc1ccc(-c2cncc(C(=O)O)c2)s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2E1 P05181 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2A6 P11509 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2B6 P20813 1/20 0.55
CYP2C19 P33261 1/20 0.55
MKNK1 Q9BUB5 2/20 0.47
MKNK2 Q9HBH9 2/20 0.47
MAPT P10636 1/20 0.41
APP P05067 1/20 0.40
HCAR2 Q8TDS4 5/20 0.40
POLB P06746 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.40
DDO Q99489 1/20 0.40
CHEK1 O14757 1/20 0.40
EP300 Q09472 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30566622 0.87 CYP2E1 (0.51) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL28936755 0.83 CYP2E1 (0.46) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2557368 0.79 HDAC1 (0.57) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2015912 0.78 APP (0.54) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2559036 0.78 CA12 (0.44) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL18003869 0.77 CYP2A6 (0.59) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2554144 0.77 CYP2E1 (0.41) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2553486 0.77 TPMT (0.46) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6
SCHEMBL2556101 0.77 CYP3A4 (0.60) CYP3A4CYP2A6CYP2C9CYP2C19MKNK1
SCHEMBL2552033 0.77 HCAR1 (0.41) CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed