Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.96 |
| ▸ | MAOB | P27338 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561900 | 1.00 | MAOA (0.96) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL670018 | 0.98 | MAOA (1.00) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL670019 | 0.98 | MAOA (1.00) | MAOAMAOBALDH1A1MAPTHTT | |
| Benzene SCHEMBL10803509 | 0.89 | MAOA (0.82) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL29785641 | 0.86 | MAOA (0.77) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL2470956 | 0.86 | MAOA (0.77) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL275526 | 0.86 | MAOA (0.77) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL2557888 | 0.84 | MAOA (0.74) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL4417764 | 0.82 | MAOA (0.71) | MAOAMAOBALDH1A1MAPTHTT | |
| SCHEMBL10596667 | 0.82 | MAOA (0.71) | MAOAMAOBALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205657-A1 | OSMIUM (II) ARENE IMINO ANTI-CANCER COMPLEXES | University of Warwick (GB) | 2017-08-16 | — | — | EP | disclosed |
| US-9598448-B2 | Osmium (II) arene imino anti-cancer complexes | UNIVERSITY OF WARWICK (GB) | 2017-03-21 | — | — | US | disclosed |
| EP-2560980-B1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIV WARWICK (GB) | 2017-01-25 | — | — | EP | disclosed |
| US-20160272663-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2016-09-22 | — | — | US | disclosed |
| US-9296772-B2 | Osmium (II) arene azo anti-cancer complexes | THE UNIVERSITY OF WARWICK (GB) | 2016-03-29 | — | — | US | disclosed |
| EP-2560980-A2 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | University of Warwick (GB) | 2013-02-27 | — | — | EP | disclosed |
| US-20130040925-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2013-02-14 | — | — | US | disclosed |
| WO-2011131925-A2 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | UNIVERSITY OF WARWICK (GB) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272663-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | TP53, SLC30A5, IDH1 | MAOA 4342/4885MAOB 3959/4885ALDH1A1 1108/4885 |
| US-20130040925-A1 | OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES | TP53, SLC30A5, IDH1 | MAOA 4342/4885MAOB 3959/4885ALDH1A1 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.