Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569997 | 0.87 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2881471 | 0.85 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL2568013 | 0.82 | EPHX2 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2569996 | 0.77 | MAPT (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4110966 | 0.73 | MAPT (0.72) | NPC1RAB9ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL4118553 | 0.71 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13695917 | 0.70 | MAPT (0.68) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4116098 | 0.70 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8251624 | 0.69 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL4118206 | 0.69 | MAPT (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732901-B1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | AICURIS GMBH & CO KG (DE) | 2011-11-02 | — | — | EP | disclosed |
| EP-1732901-A1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | Bayer HealthCare AG (DE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092865-A1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | BAYER HEALTHCARE AG (DE) | 2005-10-06 | — | — | WO | disclosed |