Sugi Predict

Sugi Predict / Compounds / SCHEMBL2562264

SCHEMBL2562264

SCHEMBL2562264

CCOC(=O)c1cncc2c(Nc3ccc([Si](C)(C)C)cc3F)c(C(=O)OCc3ccccc3)oc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP2K1 Q02750 1/20 0.40
▸ BRAF P15056 7/20 0.38
▸ MAPT P10636 2/20 0.38
▸ EIF2AK3 Q9NZJ5 5/20 0.37
▸ FTO Q9C0B1 1/20 0.37
▸ TP53 P04637 1/20 0.36
▸ THRB P10828 1/20 0.35
▸ CCNB2 O95067 1/20 0.35
▸ CDK1 P06493 1/20 0.35
▸ CCNB1 P14635 1/20 0.35
▸ CCNA2 P20248 1/20 0.35
▸ CCNE1 P24864 1/20 0.35
▸ CDK2 P24941 1/20 0.35
▸ CCNB3 Q8WWL7 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ RAF1 P04049 1/20 0.35
▸ DHODH Q02127 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2565053 0.89 MAP2K1 (0.44) MAP2K1BRAFMAPTEIF2AK3TP53
SCHEMBL2565520 0.85 MAP2K1 (0.52) MAP2K1BRAFMAPTEIF2AK3THRB
SCHEMBL2565490 0.85 MAP2K1 (0.42) MAP2K1BRAFMAPTEIF2AK3TP53
SCHEMBL2559561 0.85 MAP2K1 (0.42) MAP2K1BRAFEIF2AK3TP53THRB
SCHEMBL2565971 0.84 MAP2K1 (0.45) MAP2K1BRAFEIF2AK3TP53THRB
SCHEMBL2569311 0.84 MAP2K1 (0.45) MAP2K1BRAFMAPTEIF2AK3FTO
SCHEMBL2567376 0.83 MAP2K1 (0.44) MAP2K1BRAFMAPTEIF2AK3TP53
SCHEMBL4988785 0.81 MAP2K1 (0.42) MAP2K1BRAFMAPTEIF2AK3THRB
SCHEMBL2566055 0.78 MAP2K1 (0.53) MAP2K1BRAFMAPTEIF2AK3TSHR
SCHEMBL2562770 0.77 L3MBTL1 (0.44) MAPTCCNB2CDK1CCNB1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069354-B1 Aza-benzofuranyl compounds and methods of use GENENTECH INC (US) 2011-11-02 — — EP disclosed
EP-2069354-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE Genentech, Inc. (US) 2009-06-17 — — EP disclosed
US-20080085886-A1 Anticancer and/or antiinflammatory activity, MEK (MAP kinase kinase) inhibitors; for example, 3-(2-Fluoro-4-iodo-phenylamino)-furo[3,2-c]pyridine-2-carboxylic acid ((R)-2,3-dihydroxy-propoxy)-amide GENENTECH, INC. 2008-04-10 — — US disclosed
US-20080085886-A1 Anticancer and/or antiinflammatory activity, MEK (MAP kinase kinase) inhibitors; for example, 3-(2-Fluoro-4-iodo-phenylamino)-furo[3,2-c]pyridine-2-carboxylic acid ((R)-2,3-dihydroxy-propoxy)-amide GENENTECH, INC. 2008-04-10 — — US disclosed
WO-2008024725-A1 AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2008-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080085886-A1 Anticancer and/or antiinflammatory activity, MEK (MAP kinase kinase) inhibitors; for example, 3-(2-Fluoro-4-iodo-phenylamino)-furo[3,2-c]pyridine-2-carboxylic acid ((R)-2,3-dihydroxy-propoxy)-amide MAP3K2, MAP3K1, MAP2K2 MAP2K1 10/4885BRAF 42/4885MAPT 4315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.