Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25624321 | 0.94 | ALK (0.31) | JAK2 | |
| SCHEMBL25624333 | 0.89 | ALK (0.32) | JAK2 | |
| SCHEMBL25632048 | 0.88 | JAK2 (0.34) | JAK2 | |
| SCHEMBL25624306 | 0.87 | ALK (0.32) | JAK2 | |
| SCHEMBL30228145 | 0.84 | ALK (0.32) | JAK2 | |
| SCHEMBL25624308 | 0.84 | ALK (0.32) | JAK2 | |
| SCHEMBL28982093 | 0.82 | ALK (0.31) | JAK2 | |
| SCHEMBL25630518 | 0.82 | ALK (0.36) | JAK2 | |
| SCHEMBL30295457 | 0.82 | ALK (0.31) | JAK2 | |
| SCHEMBL25624323 | 0.81 | ALK (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667649-B2 | Heteroaromatic macrocyclic ether chemotherapeutic agents | NUVALENT, INC. (US) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667649-B2 | Heteroaromatic macrocyclic ether chemotherapeutic agents | CYP2C8, ABCB1, PAICS | JAK2 688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.