Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25624308 | 1.00 | ALK (0.32) | ALKMAPTHTTRAB9AKCNH2 | |
| SCHEMBL25624989 | 0.93 | ALK (0.32) | ALKKCNH2 | |
| SCHEMBL25624334 | 0.93 | ALK (0.31) | ALKKCNH2 | |
| SCHEMBL25624332 | 0.89 | S1PR4 (0.31) | ALKJAK2 | |
| SCHEMBL25624330 | 0.88 | ALK (0.30) | ALKKCNH2 | |
| SCHEMBL25624327 | 0.87 | RIPK1 (0.32) | MAPTHTTRAB9A | |
| SCHEMBL28998953 | 0.87 | ALK (0.44) | ALKKCNH2JAK2 | |
| SCHEMBL30228169 | 0.87 | ALK (0.44) | ALKKCNH2JAK2 | |
| SCHEMBL30295457 | 0.87 | ALK (0.31) | ALKJAK2 | |
| SCHEMBL28982093 | 0.87 | ALK (0.31) | ALKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916196-A | Heteroaromatic macrocyclic ether chemotherapeutic agents | 纽威伦特公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4146205-A1 | HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS | Nuvalent, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |