Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227878 | 1.00 | JAK2 (0.33) | JAK2MAPTALK | |
| SCHEMBL25624939 | 0.94 | ALK (0.32) | JAK2ALK | |
| SCHEMBL30228042 | 0.93 | ALK (0.32) | JAK2ALK | |
| SCHEMBL25624054 | 0.93 | ALK (0.32) | JAK2ALK | |
| SCHEMBL25624941 | 0.91 | JAK2 (0.31) | JAK2ALK | |
| SCHEMBL25624340 | 0.91 | ALK (0.31) | ALK | |
| SCHEMBL25624057 | 0.86 | MAPT (0.35) | MAPT | |
| SCHEMBL30228323 | 0.85 | JAK2 (0.33) | JAK2MAPTALK | |
| SCHEMBL25624144 | 0.85 | JAK2 (0.33) | JAK2MAPTALK | |
| SCHEMBL28998902 | 0.85 | RIPK1 (0.33) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667649-B2 | Heteroaromatic macrocyclic ether chemotherapeutic agents | NUVALENT, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| CN-115916196-A | Heteroaromatic macrocyclic ether chemotherapeutic agents | 纽威伦特公司 | 2023-04-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667649-B2 | Heteroaromatic macrocyclic ether chemotherapeutic agents | CYP2C8, ABCB1, PAICS | JAK2 688/4885MAPT 3344/4885ALK 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.