Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.66 |
| ▸ | PDE6D | O43924 | 3/20 | 0.66 |
| ▸ | PDE6A | P16499 | 3/20 | 0.66 |
| ▸ | PDE6G | P18545 | 3/20 | 0.66 |
| ▸ | PDE6B | P35913 | 3/20 | 0.66 |
| ▸ | PDE6C | P51160 | 3/20 | 0.66 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566057 | 0.94 | PDE5A (0.60) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16188257 | 0.92 | PDE5A (0.61) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2559792 | 0.91 | GUSB (0.59) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2564934 | 0.87 | PDE5A (0.59) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2562266 | 0.84 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16188246 | 0.83 | PDE5A (0.67) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2568303 | 0.81 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2563344 | 0.80 | PDE5A (0.74) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2568366 | 0.80 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2576880 | 0.80 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |