Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.59 |
| ▸ | PDE5A | O76074 | 17/20 | 0.58 |
| ▸ | PDE6D | O43924 | 2/20 | 0.54 |
| ▸ | PDE6A | P16499 | 2/20 | 0.54 |
| ▸ | PDE6G | P18545 | 2/20 | 0.54 |
| ▸ | PDE6B | P35913 | 2/20 | 0.54 |
| ▸ | PDE6C | P51160 | 2/20 | 0.54 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 3/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562540 | 0.91 | PDE5A (0.66) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2566057 | 0.90 | PDE5A (0.60) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16188257 | 0.88 | PDE5A (0.61) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2564939 | 0.86 | GUSB (0.60) | GUSBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL2567594 | 0.85 | GUSB (0.59) | GUSBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL2562186 | 0.85 | GUSB (0.59) | GUSBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL2565233 | 0.81 | GUSB (0.62) | GUSBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL2568080 | 0.80 | GUSB (0.53) | GUSBPDE5APDE1APDE1BPDE1C | |
| SCHEMBL2564934 | 0.77 | PDE5A (0.59) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2567731 | 0.77 | PDE5A (0.61) | GUSBPDE5APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |