Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | GCK | P35557 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554235 | 0.88 | RAB9A (0.60) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2556997 | 0.86 | KDM4E (0.63) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2560460 | 0.84 | KDM4E (0.61) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2558948 | 0.84 | KDM4E (0.63) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2554108 | 0.84 | KDM4E (0.63) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2557090 | 0.84 | KDM4E (0.63) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2555806 | 0.84 | KDM4E (0.63) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2554299 | 0.84 | ABL1 (0.67) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2560043 | 0.83 | KDM4E (0.60) | KDM4EABL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2557283 | 0.83 | SMN1; SMN2 (0.61) | KDM4EABL1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |