Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.60 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423674 | 0.84 | PDE10A (0.71) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1695170 | 0.83 | PDE10A (0.57) | PDE10ALGALS3PDE4DCYP1A2CYSLTR1 | |
| SCHEMBL1423605 | 0.82 | PDE10A (0.60) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL2566156 | 0.81 | PDE10A (0.57) | PDE10ALGALS3PDE4DCYP1A2 | |
| SCHEMBL1423981 | 0.81 | PDE10A (0.67) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1423926 | 0.79 | PDE10A (0.64) | PDE10ALGALS3PDE4D | |
| SCHEMBL9719806 | 0.79 | PDE10A (0.63) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL8485790 | 0.79 | PDE10A (0.63) | PDE10ACYP1A2CYSLTR2CYSLTR1GPBAR1 | |
| SCHEMBL1423537 | 0.78 | PDE10A (0.64) | PDE10ALGALS3PDE4D | |
| SCHEMBL1423652 | 0.78 | PDE10A (0.64) | PDE10ALGALS3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |