Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 19/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282564 | 0.87 | TTK (0.77) | TTKAURKBMAPK8 | |
| SCHEMBL2561009 | 0.81 | TTK (0.72) | TTKAURKBINCENPMAPK8 | |
| SCHEMBL2571860 | 0.81 | TTK (1.00) | TTKAURKBINCENP | |
| SCHEMBL12280706 | 0.77 | TTK (0.68) | TTKAURKBINCENP | |
| SCHEMBL2567517 | 0.76 | TTK (1.00) | TTKMAPK8 | |
| SCHEMBL2582534 | 0.75 | TTK (1.00) | TTKAURKBINCENP | |
| SCHEMBL2569400 | 0.75 | TTK (1.00) | TTKAURKB | |
| SCHEMBL2564814 | 0.74 | TTK (0.67) | TTKAURKBMAPK8 | |
| SCHEMBL12282759 | 0.74 | TTK (1.00) | TTKMAPK8 | |
| SCHEMBL2567567 | 0.74 | TTK (1.00) | TTKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |