Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 17/20 | 1.00 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575066 | 0.92 | TTK (0.85) | TTKCSNK1DAURKBINCENPCA2 | |
| SCHEMBL12281862 | 0.90 | TTK (0.82) | TTKCSNK1DAURKBINCENPPLK4 | |
| SCHEMBL12281666 | 0.90 | TTK (0.82) | TTKCSNK1DAURKBINCENPPLK4 | |
| SCHEMBL2573137 | 0.88 | TTK (1.00) | TTKCSNK1DAURKBINCENPPLK4 | |
| SCHEMBL2571860 | 0.87 | TTK (1.00) | TTKAURKBINCENPMAPK3MAPK1 | |
| SCHEMBL12284560 | 0.83 | TTK (0.77) | TTKAURKBINCENPMAPK1 | |
| SCHEMBL12281670 | 0.82 | TTK (1.00) | TTKAURKBINCENP | |
| SCHEMBL2564968 | 0.82 | TTK (1.00) | TTKAURKBPLK4CHEK2CYP3A4 | |
| SCHEMBL2582534 | 0.81 | TTK (1.00) | TTKAURKBINCENP | |
| SCHEMBL12907323 | 0.80 | TTK (0.66) | TTKCSNK1DCA2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |