Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | MLNR | O43193 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757414 | 0.75 | HDAC8 (0.47) | GHSR | |
| SCHEMBL28620011 | 0.67 | POLB (0.49) | — | |
| SCHEMBL31508335 | 0.66 | CYP11B1 (0.41) | PARP1CYP11B1CHRNB2CHRNA4FPR2 | |
| SCHEMBL12534333 | 0.65 | — | — | |
| SCHEMBL2564481 | 0.65 | PARP1 (0.34) | PARP1CYP11B1CHRNB2CHRNA4FPR2 | |
| SCHEMBL27631410 | 0.64 | PARP1 (0.41) | PARP1 | |
| SCHEMBL8741574 | 0.64 | — | — | |
| SCHEMBL1273762 | 0.64 | — | — | |
| SCHEMBL7290609 | 0.62 | — | — | |
| SCHEMBL14839095 | 0.62 | GRM2 (0.48) | PARP1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563795-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | MethylGene Inc. (CA) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011127567-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2011-10-20 | — | — | WO | disclosed |