Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 11/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021614 | 1.00 | BRD4 (0.49) | BRD4CREBBPMAOAMAOBDRD2 | |
| SCHEMBL691343 | 0.87 | HTR2C (0.47) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL2015193 | 0.87 | HTR2C (0.47) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL2014689 | 0.83 | CREBBP (0.53) | BRD4CREBBPMAOAMAOBSLC6A2 | |
| SCHEMBL693191 | 0.83 | HTR2C (0.58) | MAOAMAOBHTR2CHTR2BHTR2A | |
| SCHEMBL691878 | 0.83 | HTR2C (0.58) | MAOAMAOBHTR2CHTR2BHTR2A | |
| SCHEMBL2014698 | 0.82 | CREBBP (0.52) | BRD4CREBBPMAOAMAOBHTR2C | |
| SCHEMBL2019541 | 0.81 | HTR2C (0.42) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL693785 | 0.80 | HTR1A (0.43) | CREBBPMAOBDRD2HTR2CHTR2B | |
| SCHEMBL693335 | 0.79 | MAOB (0.46) | CREBBPMAOAMAOBHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |