Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567788 | 0.81 | MTOR (0.49) | MTORPIK3R1ALDH1A1GAAHPGD | |
| SCHEMBL2597500 | 0.76 | MTOR (0.56) | MTORPIK3R1PIK3CAPIK3CG | |
| SCHEMBL1359915 | 0.76 | MTOR (0.55) | MTORPIK3R1PIK3CAPIK3CG | |
| SCHEMBL2564539 | 0.76 | MTOR (0.49) | MTORPIK3R1PIK3CAPIK3CG | |
| SCHEMBL2597626 | 0.75 | MTOR (0.58) | MTORPIK3R1PIK3CAPIK3CGPIK3CD | |
| SCHEMBL3049847 | 0.74 | MTOR (0.43) | MTORPIK3R1ALDH1A1GAAHPGD | |
| Hydrochloric Acid SCHEMBL2566544 | 0.74 | MTOR (0.42) | MTORPIK3R1ALDH1A1GAAHPGD | |
| SCHEMBL12110760 | 0.73 | PIK3CA (0.75) | MTORPIK3CAPIK3CG | |
| SCHEMBL2597635 | 0.71 | MTOR (0.59) | MTORPIK3R1PIK3CAPIK3CG | |
| SCHEMBL2568692 | 0.71 | MTOR (0.49) | MTORPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382207-A2 | PI3K/MTOR KINASE INHIBITORS | Xcovery Holding Company LLC (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010056320-A2 | PI3K/MTOR KINASE INHIBITORS | TYROGENEX, INC. (US) | 2010-05-20 | — | — | WO | disclosed |