Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.61 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL1B | P01584 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25235036 | 0.92 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25272452 | 0.84 | DDB1 (0.63) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25281672 | 0.84 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30830958 | 0.83 | DDB1 (0.64) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25225393 | 0.83 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29218135 | 0.83 | CRBN (0.53) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29218133 | 0.83 | CRBN (0.53) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25278392 | 0.83 | DDB1 (0.63) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25233598 | 0.82 | DDB1 (0.64) | CRBNDDB1IKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL23301271 | 0.82 | DDB1 (0.63) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4446324-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) | 2024-10-16 | — | — | EP | claimed |
| CN-116239566-A | E3 ubiquitin ligase ligand compound, protein degradation agent developed based on ligand compound and application thereof | 标新生物医药科技(上海)有限公司 | 2023-06-09 | — | — | CN | claimed |
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |