Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218133 | 0.93 | CRBN (0.53) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31390315 | 0.86 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29259962 | 0.85 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24834648 | 0.85 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29986440 | 0.85 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25647346 | 0.83 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24481010 | 0.83 | DDB1 (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24819465 | 0.82 | CRBN (0.58) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30135913 | 0.82 | CRBN (0.58) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29260231 | 0.81 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586230-A | PROTAC compound for degrading EBNA1, preparation method and application thereof | 南方医科大学深圳医院 | 2024-02-23 | — | — | CN | disclosed |