Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 8/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25649396 | 0.81 | BTK (0.42) | BTKLCK | |
| SCHEMBL30063464 | 0.78 | BTK (0.41) | BTKLCK | |
| SCHEMBL23816213 | 0.78 | BTK (0.41) | BTKLCK | |
| SCHEMBL26114267 | 0.78 | BTK (0.41) | BTKLCK | |
| SCHEMBL30063405 | 0.78 | BTK (0.41) | BTKLCK | |
| SCHEMBL19876263 | 0.77 | BTK (0.60) | BTKLCK | |
| SCHEMBL17645703 | 0.76 | BTK (0.46) | BTKLCK | |
| SCHEMBL29124814 | 0.76 | BTK (0.46) | BTKLCK | |
| SCHEMBL30063476 | 0.76 | BTK (0.44) | BTKLCK | |
| SCHEMBL23816068 | 0.76 | BTK (0.44) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |
| WO-2023066350-A1 | CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS | 标新生物医药科技(上海)有限公司 | 2023-04-27 | — | — | WO | disclosed |