Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.56 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16250614 | 0.80 | ABL1 (0.80) | ABL1ABL2CSF1RGAKMLNR | |
| SCHEMBL17471717 | 0.78 | CSF1R (0.57) | ABL1CSF1RCYP3A4KCNH2ROR1 | |
| SCHEMBL14705592 | 0.78 | CSF1R (0.55) | ABL1CSF1RCYP3A4DDR1KCNH2 | |
| SCHEMBL16644546 | 0.78 | ABL1 (0.53) | ABL1ABL2CSF1RGAKMLNR | |
| Trifluoroacetic Acid SCHEMBL30879813 | 0.76 | ABL1 (0.58) | ABL1ABL2CSF1RGAKMLNR | |
| SCHEMBL30458494 | 0.75 | CSF1R (0.52) | ABL1CSF1RROR1 | |
| SCHEMBL15096062 | 0.75 | ROR1 (0.67) | ABL1ABL2CSF1RGAKMLNR | |
| SCHEMBL29506341 | 0.75 | CSF1R (0.67) | ABL1CSF1RCYP3A4KCNH2ROR1 | |
| SCHEMBL22580709 | 0.75 | CSF1R (0.61) | ABL1CSF1RCYP3A4FGFR1FGFR2 | |
| SCHEMBL17471729 | 0.75 | CSF1R (0.56) | ABL1ABL2CSF1RGAKMLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |