SCHEMBL30458494

SCHEMBL30458494

Cc1ccc(-c2ccccc2C(N)=O)cc1C#Cc1cnc2cccnn12

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.52
ROR1 Q01973 14/20 0.51
ABL1 P00519 5/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22243490 0.83 CSF1R (0.66) CSF1RROR1ABL1
SCHEMBL29493472 0.83 CSF1R (0.66) CSF1RROR1ABL1
SCHEMBL5137513 0.79 CSF1R (0.48) CSF1RROR1ABL1
SCHEMBL15096062 0.77 ROR1 (0.67) CSF1RROR1ABL1
SCHEMBL29506341 0.77 CSF1R (0.67) CSF1RROR1ABL1
SCHEMBL14705592 0.77 CSF1R (0.55) CSF1RROR1ABL1
SCHEMBL17471717 0.77 CSF1R (0.57) CSF1RROR1ABL1
SCHEMBL30010219 0.75 CSF1R (0.72) CSF1RROR1ABL1
Trifluoroacetic Acid SCHEMBL30879813 0.74 ABL1 (0.58) CSF1RROR1ABL1
SCHEMBL15088585 0.74 CSF1R (0.62) CSF1RROR1ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 WO claimed