Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.65 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.65 |
| ▸ | TNF | P01375 | 2/20 | 0.62 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.56 |
| ▸ | IL1B | P01584 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19451376 | 1.00 | CRBN (0.65) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL20437036 | 0.92 | CRBN (0.75) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL2049325 | 0.92 | CRBN (0.75) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL2051062 | 0.92 | CRBN (0.75) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL2049327 | 0.92 | CRBN (0.75) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL27320525 | 0.87 | CRBN (0.67) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL29024775 | 0.85 | CRBN (0.67) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL30503680 | 0.85 | CRBN (0.67) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL20934545 | 0.85 | CRBN (0.67) | CRBNDDB1TNFIKZF3IL1B | |
| SCHEMBL30503679 | 0.85 | CRBN (0.67) | CRBNDDB1TNFIKZF3IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |