SCHEMBL25650702

SCHEMBL25650702

COC(=O)[C@@H](NC(=O)[C@@H](N)C(C)(C)C)C(C)C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.51
BIRC2 Q13490 1/20 0.44
CA12 O43570 2/20 0.44
CA14 Q9ULX7 2/20 0.44
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MAPT P10636 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GAA P10253 2/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13086357 0.82 CA12 (0.48) DPP4BIRC2CA12CA14TSHR
SCHEMBL7348800 0.81 DPP4 (0.50) DPP4BIRC2CA12CA14TSHR
Hydrochloric Acid SCHEMBL30698081 0.81 CA12 (0.47) DPP4BIRC2CA12CA14TSHR
SCHEMBL2491150 0.81 DPP4 (0.50) DPP4BIRC2CA12CA14TSHR
Hydrochloric Acid SCHEMBL7321497 0.79 DPP4 (0.48) DPP4BIRC2CA12CA14TSHR
Hydrochloric Acid SCHEMBL7324906 0.79 DPP4 (0.48) DPP4BIRC2CA12CA14TSHR
SCHEMBL10792345 0.78 CA12 (0.52) BIRC2CA12CA14TSHRSMN1; SMN2
SCHEMBL10792348 0.78 CA12 (0.52) BIRC2CA12CA14TSHRSMN1; SMN2
SCHEMBL7354071 0.78 DPP4 (0.47) DPP4BIRC2CA12CA14TSHR
SCHEMBL7354079 0.78 DPP4 (0.47) DPP4BIRC2CA12CA14TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023114516-A2 CELL-PERMEANT INHIBITORS OF VIRAL CYSTEINE PROTEASES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2023-06-22 WO disclosed