Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 7/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25656150 | 0.95 | ENPP1 (0.57) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL25656142 | 0.92 | ENPP1 (0.46) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL23762509 | 0.90 | ENPP1 (0.63) | ENPP1AURKAPDGFRBCSF1RKIT | |
| SCHEMBL30117243 | 0.90 | ENPP1 (0.63) | ENPP1AURKAPDGFRBCSF1RKIT | |
| SCHEMBL25656169 | 0.87 | ENPP1 (0.59) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL23762473 | 0.85 | ENPP1 (0.71) | ENPP1AURKAPDGFRBCSF1RKIT | |
| SCHEMBL25656168 | 0.85 | ENPP1 (0.58) | ENPP1AURKAPDGFRBKITPDGFRA | |
| SCHEMBL25656155 | 0.83 | ENPP1 (0.54) | ENPP1PDGFRB | |
| SCHEMBL25656098 | 0.82 | ENPP1 (0.50) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL25656151 | 0.81 | ENPP1 (0.69) | ENPP1SIRT2SIRT1SIRT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183212-A1 | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF | STINGRAY THERAPEUTICS INC (US) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183212-A1 | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF | ENPP1, ENPP3, PPA1 | ENPP1 1/4885SIRT2 1843/4885SIRT1 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.