Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25656163 | 0.91 | ENPP1 (0.54) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL23762459 | 0.90 | ENPP1 (0.70) | ENPP1AURKAPDGFRBPDGFRAACHE | |
| SCHEMBL25656169 | 0.88 | ENPP1 (0.59) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL25656168 | 0.83 | ENPP1 (0.58) | ENPP1AURKAPDGFRBPDGFRAKIT | |
| SCHEMBL25656100 | 0.83 | KIT (0.53) | ENPP1AURKAPDGFRBPDGFRAKIT | |
| SCHEMBL25656001 | 0.81 | ENPP1 (0.66) | ENPP1SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL25656175 | 0.81 | ENPP1 (0.53) | ENPP1SIGMAR1PDGFRB | |
| SCHEMBL25656167 | 0.81 | ENPP1 (0.57) | ENPP1AURKAPDGFRBPDGFRAACHE | |
| SCHEMBL25656170 | 0.81 | ENPP1 (0.79) | ENPP1AURKAPDGFRBPDGFRAACHE | |
| SCHEMBL23762233 | 0.80 | ENPP1 (0.69) | ENPP1AURKAPDGFRBPDGFRAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183212-A1 | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF | STINGRAY THERAPEUTICS INC (US) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183212-A1 | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF | ENPP1, ENPP3, PPA1 | ENPP1 1/4885SIRT2 1843/4885SIRT1 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.