Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.42 |
| ▸ | CCND1 | P24385 | 6/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727721 | 0.92 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL1115258 | 0.92 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL1115502 | 0.92 | CDK2 (0.45) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL12727722 | 0.92 | CDK2 (0.45) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL15875549 | 0.85 | CDK4 (0.47) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL12727791 | 0.79 | CDK4 (0.50) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL15875444 | 0.79 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL12162448 | 0.79 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL12727726 | 0.78 | CDK4 (0.39) | CDK4CDK6CCND1CDK1CCNB1 | |
| SCHEMBL12162446 | 0.77 | JAK3 (0.40) | CDK4CDK6CCND1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-B1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC (US) | 2011-11-02 | — | — | EP | disclosed |