Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 4/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25658479 | 1.00 | MDM4 (0.38) | MDM4TP53CASP3MDM2PTPN1 | |
| SCHEMBL24580391 | 1.00 | MDM4 (0.38) | MDM4TP53CASP3MDM2PTPN1 | |
| SCHEMBL31135301 | 0.91 | MDM4 (0.43) | MDM4TP53CASP3MDM2 | |
| SCHEMBL28773031 | 0.91 | MDM4 (0.43) | MDM4TP53CASP3MDM2 | |
| SCHEMBL28773032 | 0.91 | MDM4 (0.43) | MDM4TP53CASP3MDM2 | |
| SCHEMBL23157111 | 0.91 | MDM4 (0.41) | MDM4TP53CASP3MDM2 | |
| SCHEMBL24828859 | 0.90 | TLR2 (0.38) | MDM4TP53CASP3MDM2TLR2 | |
| SCHEMBL22388715 | 0.90 | TLR2 (0.38) | MDM4TP53CASP3MDM2TLR2 | |
| SCHEMBL22388716 | 0.90 | TLR2 (0.38) | MDM4TP53CASP3MDM2TLR2 | |
| SCHEMBL23156917 | 0.89 | CASP3 (0.38) | MDM4TP53CASP3MDM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230151060-A1 | CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITORY ACTION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151060-A1 | CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITORY ACTION | KRAS, NRAS, HRAS | MDM4 441/4885TP53 34/4885CASP3 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.