SCHEMBL25658982

SCHEMBL25658982

Cc1ccc(-c2ccc3c(c2)c2cc(-c4ccc(C)cc4)ccc2n3-c2cc(C#N)cc(-n3c4ccc(-c5ccc(C)cc5)cc4c4cc(-c5ccc(C)cc5)ccc43)c2-c2ccc(C#N)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
CYP2A6 P11509 1/20 0.43
MAPKAPK2 P49137 1/20 0.42
CHEK1 O14757 1/20 0.39
KIF11 P52732 1/20 0.37
KDM1A O60341 4/20 0.37
ICMT O60725 1/20 0.35
PIK3CD O00329 1/20 0.35
PIK3CA P42336 1/20 0.35
MAP4K4 O95819 1/20 0.35
AR P10275 1/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
PDE9A O76083 1/20 0.34
PDE1C Q14123 1/20 0.34
PGR P06401 2/20 0.34
EGLN2 Q96KS0 1/20 0.33
GRIA2 P42262 1/20 0.33
GRIA4 P48058 1/20 0.33
MMP3 P08254 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414138 0.93 MAPKAPK2 (0.38) ALDH1A1CYP2A6MAPKAPK2CHEK1KIF11
SCHEMBL25659011 0.91 CHEK1 (0.36) ALDH1A1CYP2A6MAPKAPK2CHEK1KIF11
SCHEMBL21414260 0.90 MAP4K4 (0.38) ALDH1A1CYP2A6MAPKAPK2CHEK1KIF11
SCHEMBL19909067 0.90 MAPKAPK2 (0.39) ALDH1A1CYP2A6MAPKAPK2CHEK1KDM1A
SCHEMBL21546946 0.88 CYP1A2 (0.39) ALDH1A1MAP4K4ARPGRGRIA2
SCHEMBL26776900 0.88 CYP11B1 (0.40) ALDH1A1CYP2A6CHEK1KDM1AICMT
SCHEMBL19909173 0.88 MAPKAPK2 (0.37) ALDH1A1CYP2A6MAPKAPK2CHEK1PIK3CD
SCHEMBL21928614 0.88 MAPKAPK2 (0.42) ALDH1A1CYP2A6MAPKAPK2CHEK1KIF11
SCHEMBL21414129 0.87 PDE9A (0.39) ALDH1A1CYP2A6MAPKAPK2ARPDE9A
SCHEMBL21109678 0.86 MAPKAPK2 (0.38) ALDH1A1CYP2A6MAPKAPK2CHEK1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3585777-B1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO LTD (KR) 2023-05-10 EP disclosed