Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.73 |
| ▸ | PDE6C | P51160 | 2/20 | 0.65 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.65 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | PDE6A | P16499 | 1/20 | 0.63 |
| ▸ | PDE6G | P18545 | 1/20 | 0.63 |
| ▸ | PDE6B | P35913 | 1/20 | 0.63 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567214 | 0.91 | PDE5A (0.74) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL2567721 | 0.91 | PDE5A (0.75) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL2567638 | 0.85 | PDE5A (1.00) | PDE5APDE6CPDE11A | |
| SCHEMBL16198797 | 0.84 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL2566308 | 0.82 | PDE5A (0.74) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL2563794 | 0.81 | PDE5A (0.81) | PDE5APDE6CPDE11A | |
| SCHEMBL7368497 | 0.80 | PDE5A (0.77) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL7002096 | 0.80 | PDE5A (0.65) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL2567268 | 0.79 | PDE5A (1.00) | PDE5APDE6CPDE11APDE6DPDE6A | |
| SCHEMBL2562505 | 0.79 | PDE5A (1.00) | PDE5APDE6CPDE11APDE6DPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | claimed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | claimed |
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |