Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25663079 | 0.96 | EGFR (0.58) | EGFRKDRSRCEPHB4FLT4 | |
| SCHEMBL25210925 | 0.88 | EGFR (0.70) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL30429634 | 0.88 | EGFR (0.70) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL26057426 | 0.87 | EGFR (0.64) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL25663172 | 0.87 | SRC (0.60) | EGFRKDRSRCEPHB4FLT4 | |
| SCHEMBL25662767 | 0.86 | SRC (0.61) | EGFRKDRSRCEPHB4FLT4 | |
| SCHEMBL30429248 | 0.84 | EGFR (0.76) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL25218983 | 0.84 | EGFR (0.76) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL26055584 | 0.83 | EGFR (0.73) | EGFRKDRSRCEPHB4FLT1 | |
| SCHEMBL25663367 | 0.80 | KDR (0.57) | EGFRKDRSRCEPHB4FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4194443-A1 | EFGR INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |