Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | LTK | P29376 | 3/20 | 0.57 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.57 |
| ▸ | CIT | O14578 | 2/20 | 0.57 |
| ▸ | GAK | O14976 | 2/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.57 |
| ▸ | STK17B | O94768 | 2/20 | 0.57 |
| ▸ | STK10 | O94804 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25247384 | 0.88 | EGFR (0.73) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL30549072 | 0.88 | EGFR (0.73) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25663378 | 0.85 | EGFR (0.53) | EGFRERBB2KDRRETFLT4 | |
| SCHEMBL30549071 | 0.85 | EGFR (0.67) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25250810 | 0.85 | EGFR (0.67) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25662767 | 0.84 | SRC (0.61) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25663172 | 0.83 | SRC (0.60) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25663079 | 0.82 | EGFR (0.58) | EGFRERBB2SRCKDRKIT | |
| SCHEMBL25663305 | 0.82 | EGFR (0.61) | EGFRERBB2KDRFLT4FLT1 | |
| SCHEMBL30429405 | 0.82 | EGFR (0.69) | EGFRERBB2SRCKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4194443-A1 | EFGR INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |