Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.53 |
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | FLT4 | P35916 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 7/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.50 |
| ▸ | TEK | Q02763 | 7/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KIF5B | P33176 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25662957 | 0.91 | EGFR (0.59) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25372394 | 0.88 | EGFR (0.72) | EGFRKDRFLT1PDGFRBAURKB | |
| SCHEMBL30429568 | 0.88 | EGFR (0.72) | EGFRKDRFLT1PDGFRBAURKB | |
| SCHEMBL25663317 | 0.86 | EGFR (0.58) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25663373 | 0.85 | EGFR (0.59) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25662578 | 0.84 | EGFR (0.56) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25662550 | 0.83 | EGFR (0.57) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25663305 | 0.82 | EGFR (0.61) | EGFRKDRFLT4FGFR1FLT1 | |
| SCHEMBL25663234 | 0.82 | EGFR (0.50) | EGFRKDRFLT1PDGFRBAURKB | |
| SCHEMBL30429405 | 0.82 | EGFR (0.69) | EGFRKDRFLT1PDGFRBAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4194443-A1 | EFGR INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |