Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | FPR3 | P25089 | 2/20 | 0.30 |
| ▸ | FPR2 | P25090 | 2/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450426 | 0.87 | BACE1 (0.45) | BACE1APP | |
| SCHEMBL447140 | 0.85 | BACE1 (0.45) | BACE1CTSDFPR3FPR2 | |
| SCHEMBL2561886 | 0.84 | BACE1 (0.36) | BACE1CTSDAPPMAPKAPK2 | |
| SCHEMBL447872 | 0.79 | BACE1 (0.50) | BACE1APP | |
| SCHEMBL449691 | 0.78 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL448287 | 0.76 | BACE1 (0.49) | BACE1APP | |
| SCHEMBL445893 | 0.75 | BACE1 (0.43) | BACE1CTSDAPP | |
| SCHEMBL2557900 | 0.74 | BACE1 (0.36) | BACE1CTSDAPP | |
| SCHEMBL449162 | 0.71 | BACE1 (0.46) | BACE1CTSDAPP | |
| SCHEMBL447947 | 0.71 | BACE1 (0.61) | BACE1CTSDAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |